EN
  • 业务咨询

    中国:

    Email: marketing@medicilon.com.cn

    业务咨询专线:400-780-8018

    (仅限服务咨询,其他事宜请拨打川沙总部电话)

    川沙总部电话: +86 (21) 5859-1500

    海外:

    +1(781)535-1428(U.S.)

    0044 7790 816 954 (Europe)

    Email:marketing@medicilon.com

在线留言×
点击切换
Customer Center
客户中心

PDE1是与中枢和外周疾病密切相关的药物靶点,研究人员合成一种PDE1 抑制剂在大鼠肝微粒体中具有良好的代谢稳定性。其中稳定性测试通过美迪西进行

2023-07-06
|
访问量:

Phosphodiesterase-1 (PDE1) is a promising drug target closely related to central and peripheral diseases. Compound 2j with the IC50 of 21 nM against PDE1B, shows good metabolic stability in the rat liver microsomes. Stability test in the rat liver microsomes were performed by Medicilon.

61.jpg

Reference:

Bei Zhang, et al. Design, synthesis and biological evaluation of novel pyrazolopyrimidone derivatives as potent PDE1 inhibitors. Bioorg Chem. 2021 Sep;114:105104. doi: 10.1016/j.bioorg.2021.105104. 

相关新闻
×
搜索验证
点击切换